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By the time you're depending on active antimalware/antivirus to do its job, it's usually too late anyway, especially if the malware is undetected. It can help, but it shouldn't be your only defense.
A secure browser with ad blocking, a properly configured firewall, sandboxing/virtualization software, locked down file system permissions, along with some common sense and safe practices is the way to go.
I personally use Chrome (with uBlock Origin and uMatrix), Comodo Personal Firewall, Sandboxie, VMWare, Microsoft EMET, and finally Microsoft Security Essentials, along with some other niche security software.
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