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Antiviruses in their classical meaning are completely useless and by definition fall far back behind offensive side. And quite often they even increase attack surface, basically doing the opposite of what they're supposed to do.
My bet is on sandboxing/isolation. And since it may be tedious to start a full-fledged VM for every downloaded executable and bigger software tend to have more bugs including security ones, light and secure software relying on documented Windows principles like ReHIPS is my choice.
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