You are encountering anti-debugger techniques.
ScyllaHide for example can help you defeat these though Obsidium is quite hard and may not even work in the latest version requiring some custom scripts or tools instead. See:
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ScyllaHide is an open-source x64/x86 usermode Anti-Anti-Debug library.
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https://github.com/nihilus/ScyllaHide
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But perhaps you should learn about the nice Search feature of the forum first as it can certainly help novices who have a bit of information go down the right path:
https://forum.exetools.com/showthread.php?t=16245
And after you read and properly digest that discussion, probably if you are new to this, you would be best trying some easier unpack targets first before going to a difficult one but this depends on how you work best.