Maybe "Syser" is now a good debugger (I don't really like it for various reasons), but as soon as Windows Vista comes out, it will have the same fate as SoftICE: It will be useless since only the Microsoft debugger can load unsigned drivers, just like MarkusO pointed out above.

And you have to understand what SoftICE is designed to be. It is not a cracking tool, it is a professional debugger. Loading and saving memory is nothing which an application of this kind needs to able to do, since the typical user working with SoftICE is a programmer who has the source code of his own application. Therefore he can always change his source to read/write some memory.