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I'm not sure about editing resources to change shortcut.
You can probably use a system wide keyboard hook. So in your example if you want keypress F2 to behave as F1 then once you detect F2 keypress, you will send F1 keypress message.
Not the perfect example but this may be helpful:
http://www.codeproject.com/Articles/6362/Global-System-Hooks-in-NET
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