Patching Module (DLL) in memory?

[FEARHQ]

I have a target which I need to patch a dll in memory without touching the actual dll on the local disk. This dll is very likely to be updated, however the code I wish to patch is unlikely to change. So far, I am using Process Patcher by The Welsh Dragon, however I find it's strict patching abilities inapropriate... Does anyone know of a nice "Search N Destroy" type patcher (wildcards not necessary, but a bonus ) that can patch a loaded module (dll) in a target?